Ultrasound-mediated drug-free theranostics for treatment of prostate cancer

Lipid-shelled nanobubbles (NBs) can be visualized and activated using noninvasive ultrasound (US) stimulation, leading to significant bioeffects. Prior work demonstrates that active targeting of NBs to prostate-specific membrane antigen (PSMA) overexpressed in prostate cancer (PCa) results in enhanc...

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Bibliographic Details
Published in:Bioactive materials 2024-05, Vol.35, p.45-55
Main Authors: Perera, Reshani Himashika, Berg, Felipe Matias, Abenojar, Eric Chua, Nittayacharn, Pinunta, Kim, Youjoung, Wang, Xinning, Basilion, James Peter, Exner, Agata
Format: Article
Language:English
Subjects:
Acoustics
Antigens
Apoptosis
Cancer therapies
Cavitation
Cell culture
Contrast agents
Contrast enhanced ultrasound
Endocytosis
Immune response
Internalization
Lipids
Mortality
Nanobubbles
PC-3 Cells
Precision medicine
Prostate cancer
Prostate-specific membrane antigen (PSMA)
Tumors
Ultrasonic imaging
Ultrasound
Ultrasound-mediated therapy
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Summary:Lipid-shelled nanobubbles (NBs) can be visualized and activated using noninvasive ultrasound (US) stimulation, leading to significant bioeffects. Prior work demonstrates that active targeting of NBs to prostate-specific membrane antigen (PSMA) overexpressed in prostate cancer (PCa) results in enhanced cellular internalization and prolongs NB retention with persistent, cancer-cell specific acoustic activity. In this work, we hypothesized that tumor-accumulated PSMA-NBs combined with low frequency unfocused therapeutic US (TUS) will lead to selective damage and induce a specific therapeutic effect in PSMA-expressing tumors compared to PSMA-negative tumors. We observed that the internalized NBs and cellular compartments were disrupted after the PSMA-NB + TUS (targeted NB therapy or TNT) application, yet treated cells remained intact and viable. In vivo, PSMA-expressing tumors in mice receiving TNT treatment demonstrated a significantly greater extent of apoptosis (78.4 ± 9.3 %, p 
ISSN:2452-199X
2097-1192
2452-199X
DOI:10.1016/j.bioactmat.2023.12.012