Atrial natriuretic peptide secretion during development of the rat supraoptic nucleus

Since a relationship between atrial natriuretic peptide and oxytocin was recently demonstrated in the heart (Gutkowska et al., 1997), the aim of this study was to determine whether a relationship between the two peptides is present also in the rat hypothalamus. For this purpose, we measured ANP-onto...

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Bibliographic Details
Published in:European journal of histochemistry 2005-10, Vol.49 (4), p.379-384
Main Authors: Farina Lipari, E, Lipari, D, Dieli, F, Valentino, B
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Atrial Natriuretic Factor - biosynthesis
Atrial Natriuretic Factor - genetics
Atrial Natriuretic Factor - secretion
Cell Nucleolus - ultrastructure
Female
Gene Expression Regulation
Immunohistochemistry
Oxytocin - genetics
Pregnancy
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Supraoptic Nucleus - embryology
Supraoptic Nucleus - metabolism
Supraoptic Nucleus - secretion
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Summary:Since a relationship between atrial natriuretic peptide and oxytocin was recently demonstrated in the heart (Gutkowska et al., 1997), the aim of this study was to determine whether a relationship between the two peptides is present also in the rat hypothalamus. For this purpose, we measured ANP-ontogeny in the rat hypothalamus immunohistochemically and compared it with oxytocin-ontogeny which we previously studied. The results showed that the ANP-peptide and mRNA-ANP start at the 18th day of the fetal life. Our earlier data for oxytocin in the rat hypothalamus showed that only mRNA-oxytocin appeared the 18th day of foetal life (Farina Lipari et al., 2001); thus, at the 18th day of foetal life, mRNA-ANP, ANP-peptide and mRNA-oxytocin are present. We conclude that in the hypothalamus, differently from that in the heart, ANP might play a role on the synthesis of the oxytocin since ANP and its mRNA appear earlier than oxytocin.
ISSN:1121-760X
2038-8306
DOI:10.4081/966