Auditory steady-state response to chirp-modulated tones: A pilot study in patients with disorders of consciousness

• Published in: NeuroImage clinical 2020-01, Vol.27, p.102261-102261, Article 102261
• Main Authors: Binder, Marek, Górska, Urszula, Pipinis, Evaldas, Voicikas, Aleksandras, Griskova-Bulanova, Inga
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation - methods; Adult; Aged; Auditory steady-state response; Auditory system; Chirp-modulated tones; Consciousness - physiology; Consciousness Disorders - diagnostic imaging; Consciousness Disorders - physiopathology; Crs-r score; Disorders of consciousness; Electroencephalography; Evoked Potentials, Auditory - physiology; Female; Humans; Male; Middle Aged; Neuroimaging - methods; Persistent Vegetative State - diagnostic imaging; Persistent Vegetative State - physiopathology; Pilot Projects; Regular
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2020.102261

•Chirp-evoked responses were evaluated in patients with disorders of consciousness.•PLI estimates in 38–42 Hz window positively correlated with the CRS-R total score.•Gamma-range evoked activity may indicate the integrity of thalamocortical networks. Due to the problems with behavioral diagnosis of patients with prolonged DOC (disorders of consciousness), complementary approaches based on objective measurement of neural function are necessary. In this pilot study, we assessed the sensitivity of auditory chirp-evoked responses to the state of patients with severe brain injury as measured with CRS-R (Coma Recovery Scale - Revised). A convenience sample of fifteen DOC patients was included in the study. Auditory stimuli, chirp-modulated at 1–120 Hz were used to evoke auditory steady-state response (ASSR). Phase-locking index (PLI) estimates within low gamma and high gamma windows were evaluated. The PLI estimates within a narrow low gamma 38–42 Hz window positively correlated with the CRS-R total score and with the scores of the Auditory and Visual Function subscales. In the same low gamma window, significant difference in the PLIs was found between minimally conscious (MCS) and vegetative state (VS) patients. We did not observe any between-group differences nor any significant correlations with CRS-R scores in the high gamma window (80–110 Hz). Our results support the notion that the activity around 40 Hz may serve as a possible marker of the integrity of thalamocortical networks in prolonged DOC patients. Auditory steady-state responses at gamma-band frequencies highlight the role of upper parts of auditory system in evaluation of the level of consciousness in DOC patients.