Risk Factors and Pathogenic Mechanism for Secondary Primary Lung Cancer 
in Breast Cancer Patients: A Review

• Published in: Zhongguo fei ai za zhi 2022-10, Vol.25 (10), p.750-755
• Main Authors: Chen, Di, Xiao, Yaolai, Zhong, Kaize
• Format: Article
• Language: Chinese
• Subjects: Biomarkers; Breast cancer; breast cancer; second primary lung cancer; risk factors; Breast Neoplasms - complications; Cancer therapies; Carcinoma, Non-Small-Cell Lung - pathology; Cardiovascular disease; Cohort analysis; Estrogens; Female; Humans; Kinases; Lung cancer; Lung Neoplasms - pathology; Mortality; Neoplasms, Second Primary - epidemiology; Neoplasms, Second Primary - etiology; Neoplasms, Second Primary - pathology; Population; Proteins; Radiation therapy; Risk Factors; Smoking; Survival analysis; Systematic review
• ISSN: 1009-3419; 1999-6187; 1999-6187
• DOI: 10.3779/j.issn.1009-3419.2022.101.46

Breast cancer and lung cancer are the two most common malignancies in China. With the continuous improvement of breast cancer diagnosis and treatment technology, the survival time of breast cancer patients has been prolonged, and the number of breast cancer patients with second primary lung cancer (SPLC) has increased. In addition, breast cancer is the most common primary cancer in female patients with SPLC, and SPLC is the main cause of death in this population. More and more physicians pay attention to this clinical phenomenon. This paper summarized the risk and risk factors of SPLC in breast cancer patients, and elaborated its pathogenesis, in order to provide a theoretical basis for the clinical management of breast cancer patients and achieve accurate early intervention as soon as possible.
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