Deletions in the Plasmodium falciparum histidine-rich protein 2 gene: An emerging threat to the elimination of malaria in India

RDTs rely on the recognition of malarial antigens in circulating blood like parasite lactate dehydrogenase (pLDH), aldolase which are produced by all the five human malarial species, and histidine-rich protein 2 (HRP2) which is more specific to Plasmodium falciparum2. The successive consequences of...

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Bibliographic Details
Published in:Journal of vector borne diseases 2019-01, Vol.56 (1), p.85-86
Main Authors: Singh, Vineeta, Kojom, Loick
Format: Article
Language:English
Subjects:
Antigens
Diagnostic tests
Erythrocytes
Malaria
Proteins
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Summary:RDTs rely on the recognition of malarial antigens in circulating blood like parasite lactate dehydrogenase (pLDH), aldolase which are produced by all the five human malarial species, and histidine-rich protein 2 (HRP2) which is more specific to Plasmodium falciparum2. The successive consequences of misdiagnosis would lead to disease complications or deaths due to delay in providing an effective and reliable antimalarial treatment. [...]the protection/safeguard of diagnostic effectiveness of RDTs through ongoing surveillance of deletions in PfHRP2 gene is of utmost importance in India to achieve the target of malaria elimination by 2030. PLoS One 2016; 11(8): e0157949. doi: https:// doi.10.1371/journal.pone.0157949. 10.Pati P, Dhangadamajhi G, Bal M, Ranjit M.High proportions of Pfhrp2 gene deletion and performance of HRP2-based rapid diagnostic test in Plasmodium falciparum field isolates of Odisha.
ISSN:0972-9062
DOI:10.4103/0972-9062.257781