The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome

• Published in: Metabolism open 2019-06, Vol.2, p.100009-100009, Article 100009
• Main Authors: Wu, Sharon, Fahmy, Nicole, Alachkar, Houda
• Format: Article
• Language: English
• Subjects: Original Research Paper
• ISSN: 2589-9368; 2589-9368
• DOI: 10.1016/j.metop.2019.100009

Acute myeloid leukemia (AML) is characterized by rapid growth of abnormal blasts that overcrowd normal hematopoiesis. Defective mitochondrial biogenesis has been implicated in AML, which we believe is partly due to the deregulation of the mitochondrial transcription machinery (MTM) genes influencing the expression of mitochondrial genes. Here, we aim to characterize MTM gene upregulation in AML. Molecular and clinical patient data were retrieved from several public AML datasets. Kaplan-Meier survival curves were used to compare overall survival between patients, while Mann-Whitney U's non-parametric and Fisher's exact test were used for comparing continuous and categorical variables, respectively. The MTM genes and were upregulated in patients with AML compared with healthy donors. Upregulation of one or more of these genes was associated with higher percentage of peripheral blood blasts (P = 0.002), normal cytogenetic status (P = 0.027) and mutations (P = 0.009). Additionally, patients with high expression of MTM genes (Z ≥ 1) had shorter median overall survival compared with low MTM gene expression (Z