Who may benefit most from future vitamin D intervention trials: do not forget patients on continuous renal replacement therapy

[...]from the clinical side, this observation is highly relevant, since in our post hoc analysis chronic kidney disease was associated with a reduction of the survival benefit in the treatment group. [...]it is clear that CRRT is able to reduce the plasma level of proteins, foremost albumin, but als...

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Bibliographic Details
Published in:Critical care (London, England) England), 2020-04, Vol.24 (1), p.180-180, Article 180
Main Authors: Honore, Patrick M, Mugisha, Aude, Kugener, Luc, Redant, Sebastien, Attou, Rachid, Gallerani, Andrea, De Bels, David
Format: Article
Language:English
Subjects:
Acute Kidney Injury
Clinical trials
Continuous Renal Replacement Therapy
Critical care
Hemodialysis
Humans
Intensive Care Units
Letter
Mortality
Renal replacement therapy
Vitamin D
Vitamin deficiency
Vitamins
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Summary:[...]from the clinical side, this observation is highly relevant, since in our post hoc analysis chronic kidney disease was associated with a reduction of the survival benefit in the treatment group. [...]it is clear that CRRT is able to reduce the plasma level of proteins, foremost albumin, but also vitamin D-binding protein with its ligand vitamin D [12]. Amrein K, Parekh D, Westphal S, Preiser JC, Berghold A, Riedl R, Eller P, Schellongowski P, Thickett D, Meybohm P. Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study).
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-020-02910-w