Genomic epidemiology of antifungal resistance in human and avian isolates of Candida albicans : a pilot study from the One Health perspective

Stress-induced genomic changes in contribute to the adaptation of this species to various environmental conditions. Variations of the genome composition of animal-origin strains are largely unexplored and drug resistance or other selective pressures driving the evolution of these yeasts remained an...

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Bibliographic Details
Published in:Frontiers in veterinary science 2024, Vol.11, p.1345877-1345877
Main Authors: Domán, Marianna, Kaszab, Eszter, Laczkó, Levente, Bali, Krisztina, Makrai, László, Kovács, Renátó, Majoros, László, Bányai, Krisztián
Format: Article
Language:English
Subjects:
aneuploidy
drug resistance
loss of heterozygosity
whole genome sequencing
yeast
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Summary:Stress-induced genomic changes in contribute to the adaptation of this species to various environmental conditions. Variations of the genome composition of animal-origin strains are largely unexplored and drug resistance or other selective pressures driving the evolution of these yeasts remained an intriguing question. Comparative genome analysis was carried out to uncover chromosomal aneuploidies and regions with loss of heterozygosity (LOH), two mechanisms that manage genome plasticity. We detected aneuploidy only in human isolates. Bird-derived isolates showed LOH in genes commonly associated with antifungal drug resistance similar to human isolates. Our study suggests that environmental fungicide usage might exert selective pressure on infecting animals, thus contributing to the spread of potentially resistant strains between different hosts.
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2024.1345877