Metabolomics and EMT Markers of Breast Cancer: A Crosstalk and Future Perspective

Cancer cells undergo transient EMT and MET phenomena or vice versa, along with the parallel interplay of various markers, often correlated as the determining factor in decoding metabolic profiling of breast cancers. Moreover, various cancer signaling pathways and metabolic changes occurring in breas...

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Bibliographic Details
Published in:Pathophysiology (Amsterdam) 2022-05, Vol.29 (2), p.200-222
Main Authors: Pal, Ajay Kumar, Sharma, Prateek, Zia, Alishan, Siwan, Deepali, Nandave, Dipali, Nandave, Mukesh, Gautam, Rupesh K.
Format: Article
Language:English
Subjects:
breast cancer stem cells (BCSCs)
chemoresistance
EMT-transcription factors
metastasis
Review
triple-negative breast cancer (TNBC)
tumor microenvironment
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Summary:Cancer cells undergo transient EMT and MET phenomena or vice versa, along with the parallel interplay of various markers, often correlated as the determining factor in decoding metabolic profiling of breast cancers. Moreover, various cancer signaling pathways and metabolic changes occurring in breast cancer cells modulate the expression of such markers to varying extents. The existing research completed so far considers the expression of such markers as determinants regulating the invasiveness and survival of breast cancer cells. Therefore, this manuscript is crosstalk among the expression levels of such markers and their correlation in regulating the aggressiveness and invasiveness of breast cancer. We also attempted to cover the possible EMT-based metabolic targets to retard migration and invasion of breast cancer.
ISSN:1873-149X
0928-4680
1873-149X
DOI:10.3390/pathophysiology29020017