Anti-Infective Activity of Momordica charantia Extract with Molecular Docking of Its Triterpenoid Glycosides

, commonly known as bitter melon, is a fruiting plant that has been used for several diseases including infectious diseases. In this study, we report the antibacterial, antifungal, and antiviral activity of different bitter melon fruit parts originating from India and Saudi Arabia. The in vitro expe...

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Bibliographic Details
Published in:Antibiotics (Basel) 2024-06, Vol.13 (6), p.544
Main Authors: Aldholmi, Mohammed, Ahmad, Rizwan, Shaikh, Mohammad Habeeb, Salem, Ayad Mohammed, Alqurashi, Maher, Alturki, Mansour
Format: Article
Language:English
Subjects:
antibacterial
antifungal
Antiinfectives and antibacterials
Antimicrobial agents
antiviral
Antiviral activity
Bacteria
Biological activity
bitter melon
Bitter taste
DNA polymerases
Doxorubicin
Drug resistance in microorganisms
E coli
Enzymes
Fruits
Fungicides
Glycosides
Health aspects
Hepatitis
HIV
HIV (Viruses)
Human immunodeficiency virus
Infectious diseases
karavilosides
Ligands
Metabolites
Molecular docking
Momordica charantia
Natural products
Pathogens
Plant extracts
Rilpivirine
RNA-directed DNA polymerase
Seeds
Triterpenoid glycosides
Viruses
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Summary:, commonly known as bitter melon, is a fruiting plant that has been used for several diseases including infectious diseases. In this study, we report the antibacterial, antifungal, and antiviral activity of different bitter melon fruit parts originating from India and Saudi Arabia. The in vitro experiments are supported by the molecular docking of karavilosides to verify their role in the bioactivity. The antimicrobial assays revealed activity against , , and . The extracts exhibited the potent inhibition of HIV-I reverse transcriptase, with an IC50 of 0.125 mg/mL observed for the pith extract originating from Saudi Arabia and the standard drug doxorubicin. The molecular docking of karavilosides exhibited a significant affinity to reverse transcriptase comparable to Rilpivirine and higher than that of doxorubicin. These outcomes encourage the precious bioactive components of the seed and pith of the Saudi bitter melon fruits to be further studied for isolation and structure elucidation.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics13060544