Prognostic Value of Preoperative Serum Carcinoembryonic Antigen for Overall Survival and Recurrence-Free Survival in Resectable Thymic Epithelial Tumors

Introduction: Tumor markers have been shown to be closely related to the long-term survival of patients with cancer and the recurrence of various malignant tumors. However, their role in thymic epithelial tumors (TETs) remains to be elucidated. We aimed to investigate whether the preoperative tumor...

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Published in:Technology in cancer research & treatment 2022, Vol.21, p.15330338221119340-15330338221119340
Main Authors: Huang, Yang-Yu, Liu, Xuan, Liang, Shen-Hua, Hu, Yu, Ma, Guo-Wei
Format: Article
Language:English
Subjects:
Antigens
Biomarkers, Tumor
Carcinoembryonic Antigen
Humans
Medical prognosis
Multivariate analysis
Neoplasm Staging
Neoplasms, Glandular and Epithelial - diagnosis
Neoplasms, Glandular and Epithelial - surgery
Original
Phosphopyruvate Hydratase
Prognosis
Regression analysis
Retrospective Studies
Thymectomy
Thymus
Thymus Neoplasms
Tumor markers
Tumors
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Summary:Introduction: Tumor markers have been shown to be closely related to the long-term survival of patients with cancer and the recurrence of various malignant tumors. However, their role in thymic epithelial tumors (TETs) remains to be elucidated. We aimed to investigate whether the preoperative tumor biomarkers carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) could serve as independent predictors of postoperative prognosis in patients with TETs. Materials and Methods: We retrospectively included a total of 111 patients with TETs who underwent thymectomy at our hospital. Cox regression analysis was used to evaluate the statistical significance of CEA and NSE as independent predictors of overall survival (OS) and recurrence-free survival (RFS). Kaplan–Meier curves were used to present the results of our survival analyses. Results: Cox regression analysis showed that T stage, World Health Organization (WHO) histologic type, tumor size, and CEA levels served as independent prognostic factors for OS (P < .05). Whereas for RFS, multivariate analysis showed that only T stage, WHO histologic type, and drinking history were independently associated with it (P 
ISSN:1533-0346
1533-0338
DOI:10.1177/15330338221119340