Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women

• Published in: Mediators of Inflammation 2010-01, Vol.2010 (2010), p.82-88
• Main Authors: Okutsu, Mitsuharu, Sanada, Kiyoshi, Machida, Shuichi, Suzuki, Katsuhiko, Ogawa, Kishiko
• Format: Article
• Language: English
• Subjects: Aged; Aged women; Aged, 80 and over; Aging; Biological and medical sciences; C-Reactive Protein - biosynthesis; Chemokine CCL2 - biosynthesis; Female; General aspects; Health aspects; HSP70 Heat-Shock Proteins - biosynthesis; Humans; Hypertrophy; Hypertrophy - pathology; Inflammation; Inflammation - therapy; Insulin - metabolism; Insulin-Like Growth Factor I - biosynthesis; Interleukin-1 - biosynthesis; Interleukin-6 - blood; Isometric exercise; Medical sciences; Muscles - pathology; Prevention; Resistance Training; Serum Amyloid A Protein - biosynthesis; Tumor Necrosis Factor-alpha - biosynthesis; Vascular Endothelial Growth Factor A - biosynthesis; Women
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2010/171023

Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P