Improved 19F{1H} Saturation Transfer Difference Experiments for Sensitive Detection to Fluorinated Compound Bound to Proteins

The 19F{1H} saturation transfer difference (STD) method was improved for sensitive 19F detection using a human serum albumin-diflunisal complex. Because NMR (nuclear magnetic resonance) experiments with 19F detection are feasible for the selective detection of fluorinated compounds, more sensitive N...

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Bibliographic Details
Published in:Magnetochemistry 2019-03, Vol.5 (1), p.1
Main Authors: Furihata, Kazuo, Tashiro, Mitsuru
Format: Article
Language:English
Subjects:
19F NMR
Conflicts of interest
diflunisal
Experiments
fluorinated compound
Fluorination
Fluorine
Ligands
NMR
NMR-based screening
Nuclear magnetic resonance
Parameter sensitivity
Proteins
Saturation
Serum albumin
shaped pulses
Spectrum analysis
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Summary:The 19F{1H} saturation transfer difference (STD) method was improved for sensitive 19F detection using a human serum albumin-diflunisal complex. Because NMR (nuclear magnetic resonance) experiments with 19F detection are feasible for the selective detection of fluorinated compounds, more sensitive NMR methods are required to be developed for purposes of practicality. The present research focused on the investigations of 19F{1H} STD pulse techniques and experimental parameters, leading to the development of detection methods with higher sensitivity.
ISSN:2312-7481
2312-7481
DOI:10.3390/magnetochemistry5010001