Large-Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure

Background We recently reported a link between plasma levels of 2 of 84 cardiovascular disease (CVD)-related proteins and the 3 major CVDs, myocardial infarction, ischemic stroke, and heart failure. The present study investigated whether measurement of almost 10 times the number of proteins could le...

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Bibliographic Details
Published in:Journal of the American Heart Association 2021-12, Vol.10 (23), p.e023330-e023330
Main Authors: Lind, Lars, Zanetti, Daniela, Ingelsson, Martin, Gustafsson, Stefan, Ärnlöv, Johan, Assimes, Themistocles L
Format: Article
Language:English
Subjects:
Aged
Blood Proteins
Cardiovascular disease
Heart Disease Risk Factors
Heart failure
Heart Failure - blood
Heart Failure - epidemiology
Humans
Incidence
Ischemic Stroke - blood
Ischemic Stroke - epidemiology
Longitudinal Studies
Male
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - epidemiology
Original Research
Proportional Hazards Models
Proteomics
Stroke
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Summary:Background We recently reported a link between plasma levels of 2 of 84 cardiovascular disease (CVD)-related proteins and the 3 major CVDs, myocardial infarction, ischemic stroke, and heart failure. The present study investigated whether measurement of almost 10 times the number of proteins could lead to discovery of additional risk markers for CVD. Methods and Results We measured 742 proteins using the proximity extension assay in 826 male participants of ULSAM (Uppsala Longitudinal Study of Adult Men) who were free from CVD at the age of 70 years. Cox proportional hazards models were adjusted for age only, as well as all traditional risk factors. During a 12.5-year median follow-up (maximal, 22.0 years), 283 incident CVDs occurred. Forty-one proteins were significantly (false discovery rate
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.121.023330