Cranberry Polyphenols: Natural Weapons against Dental Caries

Bioactive polyphenol components of cranberry ( ) are known to have virulence attenuating effects against several cariogenic virulence properties responsible for dental caries pathogenesis. In particular, cranberry A-type proanthocyanidins and flavonols have demonstrated potent inhibitory effects aga...

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Bibliographic Details
Published in:Dentistry journal 2019-03, Vol.7 (1), p.20
Main Authors: Philip, Nebu, Walsh, Laurence J
Format: Article
Language:English
Subjects:
Acidification
Acids
Bacteria
Berries
Binding sites
Biofilms
Carbohydrates
Chemical compounds
Cranberries
cranberry
Dental caries
Dental plaque
Disease prevention
Enzymes
Flavonoids
Flavonols
Fruits
Glucan
Hydrophobicity
Metabolism
Microbiomes
Microorganisms
Natural products
Oral diseases
Oral hygiene
Pathogenesis
Pharmacology
Phenols
Phytochemicals
Polyphenols
Proanthocyanidins
Proteins
Review
Urogenital system
Vaccinium macrocarpon
Virulence
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Summary:Bioactive polyphenol components of cranberry ( ) are known to have virulence attenuating effects against several cariogenic virulence properties responsible for dental caries pathogenesis. In particular, cranberry A-type proanthocyanidins and flavonols have demonstrated potent inhibitory effects against cariogenic virulence targets such as bacterial acidogenicity, aciduricity, glucan synthesis, and hydrophobicity. Cranberry phenols have the ability to disrupt these cariogenic virulence properties without being bactericidal, a key quality essential for retaining the benefits of the symbiotic resident oral microbiome and preventing the emergence of resistant microbes. This review discusses the cariostatic mechanisms of specific cranberry phytochemicals and their potential use as therapeutic agents against cariogenic bacteria in the prevention and control of dental caries.
ISSN:2304-6767
2304-6767
DOI:10.3390/dj7010020