Prognostic value of intratumoral lymphocyte-to-monocyte ratio and M0 macrophage enrichment in tumor immune microenvironment of melanoma

Skin cutaneous melanoma is characterized by significant heterogeneity in its molecular, genomic and immunologic features. Whole transcriptome RNA sequencing data from The Cancer Genome Atlas of skin cutaneous melanoma (n = 328) was utilized. CIBERSORT was used to identify immune cell type compositio...

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Bibliographic Details
Published in:Melanoma management 2020-12, Vol.7 (4), p.MMT51-MMT51
Main Authors: Jairath, Neil K, Farha, Mark W, Jairath, Ruple, Harms, Paul W, Tsoi, Lam C, Tejasvi, Trilokraj
Format: Article
Language:English
Subjects:
Cancer therapies
cutaneous melanoma
Datasets
Gene expression
Immunotherapy
Lymphocytes
macrophages
Medical prognosis
Melanoma
Metastasis
monocytes
Patients
RNA sequencing
Skin cancer
Survival analysis
tumor immune microenvironment
Tumors
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Summary:Skin cutaneous melanoma is characterized by significant heterogeneity in its molecular, genomic and immunologic features. Whole transcriptome RNA sequencing data from The Cancer Genome Atlas of skin cutaneous melanoma (n = 328) was utilized. CIBERSORT was used to identify immune cell type composition, on which unsupervised hierarchical clustering was performed. Analysis of overall survival was performed using Kaplan–Meier estimates and multivariate Cox regression analyses. Membership in the lymphocyte:monocyte , monocyte  and M0 cluster was an independently poor prognostic factor for survival (HR: 3.03; 95% CI: 1.12–8.20; p = 0.029) and correlated with decreased predicted response to immune checkpoint blockade. In conclusion, an M0-macrophage-enriched, lymphocyte-to-monocyte-ratio-low phenotype in the primary melanoma tumor site independently characterizes an aggressive phenotype that may differentially respond to treatment.
ISSN:2045-0885
2045-0893
DOI:10.2217/mmt-2020-0019