The role of Exosomal miRNAs in cancer

Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in Mol Cancer 17(1):14, 2018). Exosomal miRNAs modulate processes that interfere with cancer immunity and microenvir...

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Bibliographic Details
Published in:Journal of translational medicine 2022-01, Vol.20 (1), p.6-6, Article 6
Main Authors: Li, Chuanyun, Zhou, Tong, Chen, Jing, Li, Rong, Chen, Huan, Luo, Shumin, Chen, Dexi, Cai, Cao, Li, Weihua
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Apoptosis
Body fluids
Cancer
Care and treatment
Cell Communication
Cell interactions
Cervical cancer
Drug resistance
Exosome
Exosomes
Exosomes - genetics
Exosomes - metabolism
Gene expression
Health aspects
Humans
Lung cancer
Metastases
Metastasis
Microenvironments
MicroRNA
MicroRNAs - genetics
MicroRNAs - metabolism
miRNAs
Neoplasms - pathology
Neovascularization, Pathologic - metabolism
Precision medicine
Proteins
Review
RNA polymerase
Treatment resistance
Tumor markers
Tumor Microenvironment
Tumorigenesis
Tumors
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Summary:Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in Mol Cancer 17(1):14, 2018). Exosomal miRNAs modulate processes that interfere with cancer immunity and microenvironment, and are significantly involved in tumor growth, invasion, metastasis, angiogenesis and drug resistance. Fully investigating the detailed mechanism of miRNAs in the occurrence and development of various cancers could help not only in the treatment of cancers but also in the prevention of malignant diseases. The current review highlighted recently published advances regarding cancer-derived exosomes, e.g., sorting and delivery mechanisms for RNAs. Exosomal miRNAs that modulate cancer cell-to-cell communication, impacting tumor growth, angiogenesis, metastasis and multiple biological features, were discussed. Finally, the potential role of exosomal miRNAs as diagnostic and prognostic molecular markers was summarized, as well as their usefulness in detecting cancer resistance to therapeutic agents.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-021-03215-4