Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1

Trace conditioning and extinction learning depend on the hippocampus, but it remains unclear how neural activity in the hippocampus is modulated during these two different behavioral processes. To explore this question, we performed calcium imaging from a large number of individual CA1 neurons durin...

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Bibliographic Details
Published in:eLife 2021-04, Vol.10
Main Authors: Mount, Rebecca A, Sridhar, Sudiksha, Hansen, Kyle R, Mohammed, Ali I, Abdulkerim, Moona, Kessel, Robb, Nazer, Bobak, Gritton, Howard J, Han, Xue
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Behavior
Calcium imaging
Cameras
Experiments
Extinction behavior
extinction learning
Hippocampus
Learning
Memory
Neural networks
Neurons
Neuroscience
Normal distribution
Population
Trace conditioning
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Summary:Trace conditioning and extinction learning depend on the hippocampus, but it remains unclear how neural activity in the hippocampus is modulated during these two different behavioral processes. To explore this question, we performed calcium imaging from a large number of individual CA1 neurons during both trace eye-blink conditioning and subsequent extinction learning in mice. Our findings reveal that distinct populations of CA1 cells contribute to trace conditioned learning versus extinction learning, as learning emerges. Furthermore, we examined network connectivity by calculating co-activity between CA1 neuron pairs and found that CA1 network connectivity patterns also differ between conditioning and extinction, even though the overall connectivity density remains constant. Together, our results demonstrate that distinct populations of hippocampal CA1 neurons, forming different sub-networks with unique connectivity patterns, encode different aspects of learning.
ISSN:2050-084X
2050-084X
DOI:10.7554/ELIFE.56491