A novel stable biomimetic adhesive coating for functionalization of orthodontic brackets against bacterial colonization and white spot lesions

This study aimed to evaluate the efficacy of polydopamine (PDA) functionalization on orthodontic brackets in inhibiting biofilm formation and promoting surface bioactivity to buffer the acidity of caries-causing bacteria around orthodontic brackets and prevent demineralization. The stability of the...

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Bibliographic Details
Published in:BMC oral health 2025-01, Vol.25 (1), p.23-10, Article 23
Main Authors: Singer, Lamia, Karačić, Sabina, Bierbaum, Gabriele, Palmer, Brianne, Kirschneck, Christian, Bourauel, Christoph
Format: Article
Language:English
Subjects:
Acidity
Antimicrobial agents
Bacteria
Bacterial infections
Biocompatibility
Biofilm formation
Biofilms
Biological activity
Biomimetics
Chemical properties
Coatings
Colonies
Control
Demineralization
Dental adhesives
Dental caries
Dental enamel
Dental glass ionomer cements
Dental research
Dopamine
Materials
Morphology
Optical density
Orthodontic appliances
Orthodontic brackets
Orthodontics
pH change
pH effects
Polydopamine
Protective coatings
Saliva
Scanning electron microscopy
Surface bioactivity
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Summary:This study aimed to evaluate the efficacy of polydopamine (PDA) functionalization on orthodontic brackets in inhibiting biofilm formation and promoting surface bioactivity to buffer the acidity of caries-causing bacteria around orthodontic brackets and prevent demineralization. The stability of the coating in artificial saliva (AS) and distilled water was evaluated, along with its effect on pH changes in simulated body fluid (SBF) and distilled water. Maxillary incisor orthodontic brackets underwent PDA functionalization using a dopamine hydrochloride solution following a specific protocol. Biofilm formation on both control (Br-0) and coated (Br-PDA) brackets was assessed immediately after coating and after two months of aging (Aged Br-PDA) in artificial saliva. The adherent biofilm bacteria on brackets were quantified with colony count assessment and optical density. Surface morphology, Bioactivity, and coating stability were analyzed using Scanning Electron Microscopy (SEM). Coated and uncoated samples were immersed in SBF and deionized water, and pH changes were monitored over 7 days using a pH meter. PDA-functionalized brackets, both freshly coated (1.08 OD) and aged for two months (1.6 OD), showed significantly reduced biofilm formation compared to non-functionalized control brackets (2.07 OD), with p-value 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-024-05313-3