Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis-A Systematic Review

Lipopolysaccharide (LPS) is widely used for induction of inflammation in various human tissues, including dental pulp. The purpose of this study was to summarize current medical literature focusing on (1) cell types used by researchers to simulate dental pulp inflammation, (2) LPS variants utilized...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-01, Vol.12 (1), p.138
Main Authors: Brodzikowska, Aniela, Ciechanowska, Monika, Kopka, Michał, Stachura, Albert, Włodarski, Paweł K
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Bacteria
Bacterial infections
Cytokines
Dental pulp
Dentin
Editorials
Fibroblasts
Gram-negative bacteria
Humans
Inflammation
Inflammation - metabolism
Kinases
Lipids
Lipopolysaccharides
Lipopolysaccharides - pharmacology
LPS
MicroRNAs
Mineralization
Nitric oxide
Phosphorylation
Proteins
pulp cells
pulpitis
Pulpitis - metabolism
Systematic Review
Transcription factors
Tumor necrosis factor-TNF
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Summary:Lipopolysaccharide (LPS) is widely used for induction of inflammation in various human tissues, including dental pulp. The purpose of this study was to summarize current medical literature focusing on (1) cell types used by researchers to simulate dental pulp inflammation, (2) LPS variants utilized in experimental settings and how these choices affect the findings. Our study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched for studies reporting outcomes of lipopolysaccharide application on dental pulp cells in vitro using electronic databases: MEDLINE, Web of Science and Scopus. Having gathered data from 115 papers, we aimed to present all known effects LPS has on different cell types present in dental pulp. We focused on specific receptors and particles that are involved in molecular pathways. Our review provides an essential foundation for further research using in vitro models of pulpitis.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12010138