Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

In this paper, an electrochemical method for the measurement of tryptophan (Trp) was developed based on a glassy carbon electrode modified with polyvinylpyrrolidonefunctionalized graphene (PVP-GR)/glassy carbon electrode (GCE). In 0.1 M phosphate buffer solution (PBS, pH = 2.2), compared with bare G...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2020-01, Vol.10 (1), p.125
Main Authors: He, Quanguo, Liu, Jun, Feng, Jinxia, Wu, Yiyong, Tian, Yaling, Li, Guangli, Chen, Dongchu
Format: Article
Language:English
Subjects:
Amino acids
Aqueous solutions
Biological properties
Biological samples
Buffer solutions
Carbon
Dopamine
electrochemical behavior
Electrochemistry
Electrodes
Glassy carbon
Graphene
Graphite
Melatonin
Oxidation
Pharmaceutical industry
Polyvinylpyrrolidone
Selectivity
Sensors
Serotonin
Tryptophan
Uric acid
voltammetric determination
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Summary:In this paper, an electrochemical method for the measurement of tryptophan (Trp) was developed based on a glassy carbon electrode modified with polyvinylpyrrolidonefunctionalized graphene (PVP-GR)/glassy carbon electrode (GCE). In 0.1 M phosphate buffer solution (PBS, pH = 2.2), compared with bare GCE, PVP/GCE, and GR/GCE, the oxidation peak current of Trp increased dramatically at PVP-GR/GCE. The oxidation mechanism of Trp on the PVP-GR/GCE was discussed and the experimental conditions were optimized. Under the best experimental conditions, the oxidation peak current of Trp was proportional to its concentration in the range of 0.06 µM-10.0 µM and 10.0-100.0 µM, and the limit of detection (LOD) was 0.01 µM (S/N = 3). The target modified electrode with excellent repeatability, stability and selectivity, was successfully applied to detectTrp in drugs and biological samples.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano10010125