Transorbital B-mode ultrasound for the assessment of posterior globe flattening in idiopathic intracranial hypertension: a pilot study

Background Posterior globe flattening (PGF) is a specific neuroimaging sign in patients with idiopathic intracranial hypertension (IIH), but its detection is based on subjective qualitative neuroradiological assessment. This study sought to evaluate the utility of transorbital ultrasound to detect a...

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Bibliographic Details
Published in:The ultrasound journal 2024-08, Vol.16 (1), p.39-9
Main Authors: Knoche, Theresia, Pietrock, Charlotte, Neumann, Konrad, Rossel-Zemkouo, Mirjam, Danyel, Leon Alexander
Format: Article
Language:English
Subjects:
Critical Care Medicine
Diagnostic Radiology
Diagnostic systems
Emergency Medicine
Evaluation
Females
Flattening
Hypertension
Idiopathic intracranial hypertension
Imaging
Intensive
Interventional Radiology
Medical imaging
Medicine
Medicine & Public Health
Original
Original Article
Posterior globe flattening
Radiology
Sonography
Transorbital ultrasound
Ultrasonic imaging
Ultrasonic testing
Ultrasound
Vitreous humour
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Summary:Background Posterior globe flattening (PGF) is a specific neuroimaging sign in patients with idiopathic intracranial hypertension (IIH), but its detection is based on subjective qualitative neuroradiological assessment. This study sought to evaluate the utility of transorbital ultrasound to detect and quantify PGF in IIH patients using the Posterior Globe Angle (PGA). Methods Consecutive IIH patients and healthy controls were enrolled in a prospective case-control study. Transorbital ultrasound was performed to assess the presence of PGF. For quantification of PGF, an angular measurement (PGA) was performed with the vertex centering the optic nerve at a predefined distance from the lamina cribrosa and angle legs tangentially aligned to the borders of the vitreous body. PGA measurements were compared between IIH patients and healthy controls. Additionally, the diagnostic accuracy of PGA measurements in detecting PGF was evaluated using ROC analysis. Results Thirty-one IIH patients (37.3 ± 12.3 years, 29 female) and 28 controls (33.3 ± 11.8 years, 21 female) were compared. PGF was present in 39% of IIH patients and absent in the control group. PGA 3mm measurements significantly differed between IIH and controls (116.5° ± 5.5 vs. 111.7° ± 2.9; p  
ISSN:2524-8987
2524-8987
DOI:10.1186/s13089-024-00388-z