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Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats

In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol vale...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2013-05, Vol.71 (5), p.313-319
Main Authors: Khodabandehloo, Fatimeh, Hosseini, Mahmoud, Rajaei, Ziba, Soukhtanloo, Mohammad, Farrokhi, Esmaeil, Rezaeipour, Mohsen
Format: Article
Language:English
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Summary:In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p
ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/0004-282X20130027