Therapeutic Potential of Dental Pulp Stem Cells According to Different Transplant Types

Stem cells are unspecialised cells capable of perpetual self-renewal, proliferation and differentiation into more specialised daughter cells. They are present in many tissues and organs, including the stomatognathic system. Recently, the great interest of scientists in obtaining stem cells from huma...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-12, Vol.26 (24), p.7423
Main Authors: Staniowski, Tomasz, Zawadzka-Knefel, Anna, Skośkiewicz-Malinowska, Katarzyna
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Blood vessels
Bone marrow
Cartilage
Cell differentiation
Cell proliferation
Cell self-renewal
Cytokines
Dental materials
Dental pulp
Dental Pulp - cytology
dental pulp stem cells
Dentin
endodontics
Endoplasmic reticulum
Fibroblasts
growth factor
Growth factors
Humans
Immunotherapy
In vivo methods and tests
Insulin-like growth factors
Myocardium
Nerves
Organs
Regeneration
Review
scaffold
Stem Cell Transplantation
Stem cells
Stem Cells - cytology
Teeth
Tissue engineering
Tissues
Transplantation
Transplants
Transplants & implants
Tumor necrosis factor-TNF
Xenografts
Xenotransplantation
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Summary:Stem cells are unspecialised cells capable of perpetual self-renewal, proliferation and differentiation into more specialised daughter cells. They are present in many tissues and organs, including the stomatognathic system. Recently, the great interest of scientists in obtaining stem cells from human teeth is due to their easy availability and a non-invasive procedure of collecting the material. Three key components are required for tissue regeneration: stem cells, appropriate scaffold material and growth factors. Depending on the source of the new tissue or organ, there are several types of transplants. In this review, the following division into four transplant types is applied due to genetic differences between the donor and the recipient: xenotransplantation, allotransplantation, autotransplantation and isotransplantation (however, due to the lack of research, type was not included). In vivo studies have shown that Dental Pulp Stem Cells (DPSCs)can form a dentin-pulp complex, nerves, adipose, bone, cartilage, skin, blood vessels and myocardium, which gives hope for their use in various biomedical areas, such as immunotherapy and regenerative therapy. This review presents the current in vivo research and advances to provide new biological insights and therapeutic possibilities of using DPSCs.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26247423