Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe

Antimicrobial bioassay-guided fractionation of the endophytic fungi led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B ( ), along with four known natural products ( - ). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic method...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-02, Vol.26 (4), p.1094
Main Authors: Cadelis, Melissa M, Geese, Soeren, Uy, Benedict B, Mulholland, Daniel R, van de Pas, Shara J, Grey, Alex, Weir, Bevan S, Copp, Brent R, Wiles, Siouxsie
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antifungal Agents - pharmacology
antimicrobial
Ascomycota - chemistry
Carbon-13 Magnetic Resonance Spectroscopy
Cell Death - drug effects
Dimerization
Endophytes - chemistry
Escherichia coli - drug effects
fungi
HEK293 Cells
Humans
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
MRSA
naphthoquinone dimer
Naphthoquinones - chemistry
Naphthoquinones - pharmacology
natural product
Proton Magnetic Resonance Spectroscopy
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Summary:Antimicrobial bioassay-guided fractionation of the endophytic fungi led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B ( ), along with four known natural products ( - ). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing to be moderately active towards methicillin-resistant (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26041094