Gray Matter Abnormalities in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies

Current findings on brain structural alterations in complex regional pain syndrome (CRPS) are heterogenous and controversial. This study aimed to perform a systematic review and meta-analysis to explore the significant gray matter volume (GMV) abnormalities between patients with CRPS and healthy con...

Full description

Saved in:
Bibliographic Details
Published in:Brain sciences 2022-08, Vol.12 (8), p.1115
Main Authors: Ma, Teng, Li, Ze-Yang, Yu, Ying, Yang, Yang, Ni, Min-Hua, Xie, Hao, Wang, Wen, Huang, Yu-Xiang, Li, Jin-Lian, Cui, Guang-Bin, Yan, Lin-Feng
Format: Article
Language:English
Subjects:
Bias
Brain research
Caudate nucleus
Complex regional pain syndrome
Corpus callosum
Datasets
Frontal gyrus
gray matter volume
Hypothalamus
magnetic resonance imaging
Medical imaging
Meta-analysis
Morphometry
Neostriatum
Neuroimaging
Pain
Regression analysis
Risk factors
Sensorimotor system
Sex differences
Substantia grisea
Supplementary motor area
Systematic Review
Thalamus
voxel-based morphometry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Current findings on brain structural alterations in complex regional pain syndrome (CRPS) are heterogenous and controversial. This study aimed to perform a systematic review and meta-analysis to explore the significant gray matter volume (GMV) abnormalities between patients with CRPS and healthy controls (HCs). A systematic search of the PubMed, Web of Science, and MEDLINE databases was performed, updated through 27 January 2022. A total of five studies (93 CRPS patients and 106 HCs) were included. Peak coordinates and effect sizes were extracted and meta-analyzed by anisotropic effect size–signed differential mapping (AES-SDM). Heterogeneity, sensitivity, and publication bias of the main results were checked by the Q test, jackknife analysis, and the Egger test, respectively. Meta-regression analysis was performed to explore the potential impact of risk factors on GMV alterations in patients with CRPS. The main analysis exhibited that patients with CRPS had increased GMV in the left medial superior frontal gyrus (SFGmedial.L), left striatum, and an undefined area (2, 0, −8) that may be in hypothalamus, as well as decreased GMV in the corpus callosum (CC) (extending to right supplementary motor area (SMA.R), right median cingulate/paracingulate gyri (MCC.R)), and an undefined area (extending to the right caudate nucleus (CAU.R), and right thalamus (THA.R)). Meta-regression analysis showed a negative relationship between increased GMV in the SFGmedial.L and disease duration, and the percentage of female patients with CRPS. Brain structure abnormalities in the sensorimotor regions (e.g., SFGmedial.L, SMA.R, CAU.R, MCC.R, and THA.R) may be susceptible in patients with CRPS. Additionally, sex differences and disease duration may have a negative effect on the increased GMV in SFGmedial.L.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci12081115