Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PD...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2021-11, Vol.19 (1), p.387-387, Article 387
Main Authors: Zhu, Menglu, Shi, Yi, Shan, Yifan, Guo, Junyan, Song, Xuelong, Wu, Yuhua, Wu, Miaolian, Lu, Yan, Chen, Wei, Xu, Xiaoling, Tang, Longguang
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
Biocompatibility
Biodegradability
Biodegradation
Cancer
Cancer theranostics
Cancer therapies
Carbon
Care and treatment
Cell Line, Tumor
Chemotherapy
Drug delivery
Drug delivery systems
Drugs
Efficiency
Forecasts and trends
Humans
Hydrophobicity
Immunotherapy
Indoles
Metastasis
Mice
Morphology
MPDA
Mussels
Nanodrug delivery systems
Nanomaterials
Nanomedicine
Nanoparticle Drug Delivery System
Nanoparticles
Nanostructures
Neoplasms - diagnosis
Neoplasms - therapy
Photothermal conversion
Photothermal Therapy
Polymerization
Polymers
Pore size
Porous materials
Precision medicine
Radiation therapy
Review
Technology application
Theranostic Nanomedicine
Tumors
Vehicles
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Summary:Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and photothermal conversion. However, when used as a solid nanoparticle, the application of traditional PDA is restricted because of the low drug-loading and encapsulation efficiencies of hydrophobic drugs. Nevertheless, the emergence of mesoporous materials broaden our horizon. Mesoporous polydopamine (MPDA) has the characteristics of a porous structure, simple preparation process, low cost, high specific surface area, high light-to-heat conversion efficiency, and excellent biocompatibility, and therefore has gained considerable interest. This review provides an overview of the preparation methods and the latest applications of MPDA-based nanodrug delivery systems (chemotherapy combined with radiotherapy, photothermal therapy combined with chemotherapy, photothermal therapy combined with immunotherapy, photothermal therapy combined with photodynamic/chemodynamic therapy, and cancer theranostics). This review is expected to shed light on the multi-strategy antitumor therapy applications of MPDA-based nanodrug delivery systems.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-021-01131-9