Health-Related Quality of Life in People Living With HIV With Cognitive Symptoms: Assessing Relevant Domains and Associations

This study aimed to validate and assess a comprehensive set of illness-specific health-related quality of life (HRQL) domains in people living with HIV (PLWH) with cognitive symptoms. One hundred and three HIV patients with cognitive symptoms (n = 93 male, 90.3%) were identified from two UK HIV clin...

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Bibliographic Details
Published in:Journal of the International Association of Providers of AIDS Care 2023-01, Vol.22, p.23259582231164241-23259582231164241
Main Authors: Alford, Kate, Banerjee, Sube, Daley, Stephanie, Hamlyn, Elizabeth, Trotman, Daniel, Vera, Jaime H.
Format: Article
Language:English
Subjects:
Cognition
Exploratory factor analysis
HIV
HIV Infections - complications
HIV Infections - epidemiology
HIV Infections - psychology
Human immunodeficiency virus
Humans
Locus of control
Male
Measures
Mental Health
Original
Patients
Physical disabilities
Quality of Life
Self concept
Social acceptance
Symptoms
Well being
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Summary:This study aimed to validate and assess a comprehensive set of illness-specific health-related quality of life (HRQL) domains in people living with HIV (PLWH) with cognitive symptoms. One hundred and three HIV patients with cognitive symptoms (n = 93 male, 90.3%) were identified from two UK HIV clinics and complete a series of validated scales measuring seven HRQL domains identified as important to HRQL by PLWH with cognitive impairment. These included: physical functioning, cognition, social connectedness, self-concept, HIV stigma, acceptance of and perceived control over cognitive health, and physical and mental health and wellbeing. Exploratory factor analysis confirmed that domain total scores loaded onto one main factor, representing HRQL. Scale cut-off scores revealed a significant proportion of patients scored outside the normal range on single domains (between 26.2% and 79.6%), and many patients on multiple domains (40.8% on 4 or more domains). We found evidence of poor HRQL across domains in the majority of PLWH with cognitive symptoms and identified domains driving these experiences. This provides targets for intervention development and clinical action to maintain or improve HRQL in PLWH with cognitive symptoms or impairment.
ISSN:2325-9582
2325-9574
2325-9582
DOI:10.1177/23259582231164241