Tei Index Is a Useful Adjunctive Tool in the Diagnostic Workup of Patients with Acute Myocarditis

Background: Tei index (TI) is a combined myocardial performance index, which was found to be more sensitive for overall cardiac dysfunction than systolic or diastolic parameters alone. Currently, there is only limited evidence for this measure in the context of myocarditis. Thus, TI could add additi...

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Bibliographic Details
Published in:Journal of cardiovascular development and disease 2022-08, Vol.9 (8), p.283
Main Authors: Mirna, Moritz, Schmutzler, Lukas, Vogl, Fabian, Topf, Albert, Hoppe, Uta C, Lichtenauer, Michael
Format: Article
Language:English
Subjects:
ACS
acute coronary syndrome
Acute coronary syndromes
Cardiovascular disease
Clinical medicine
Dengue fever
Diabetes
echocardiography
Ejection fraction
Heart attacks
Heart failure
Myocarditis
Regression analysis
Tei index
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Summary:Background: Tei index (TI) is a combined myocardial performance index, which was found to be more sensitive for overall cardiac dysfunction than systolic or diastolic parameters alone. Currently, there is only limited evidence for this measure in the context of myocarditis. Thus, TI could add additional benefits to conventional diagnostic workup. Methods: TI of patients with myocarditis (n = 40), acute coronary syndrome (n = 29) and controls (n = 50) was retrospectively analyzed concerning its discriminatory ability for myocarditis. Results: TI was most pathological in patients with myocarditis (median 0.41 vs. 0.35 vs. 0.31, p < 0.0001). Its discriminatory ability was better than that of EF or E/e’ (AUCs: TI: 0.71, p < 0.0001; EF: 0.57, p = 0.112; E/e’: 0.64, p = 0.983), which was also verified in logistic regression analysis (B(SE) = 0.81(0.23), p = 0.0004). The association of TI with myocarditis remained significant even after correction for confounders in propensity score weighted analysis. Conclusions: The TI showed a better discriminatory ability for myocarditis than conventional echocardiographic parameters. Since TI is easily conducted, it might be a helpful adjunctive tool to supplement conventional diagnostic modalities in patients with suspected myocarditis.
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd9080283