Molecular Pathogenesis of Human Immunodeficiency Virus-Associated Disease of Oropharyngeal Mucosal Epithelium

The oropharyngeal mucosal epithelia have a polarized organization, which is critical for maintaining a highly efficient barrier as well as innate immune functions. In human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) disease, the barrier and innate immune functions of the...

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Bibliographic Details
Published in:Biomedicines 2023-05, Vol.11 (5), p.1444
Main Author: Tugizov, Sharof M
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
B cells
Cytomegalovirus
Development and progression
Disease transmission
disruption of epithelial junctions
Epithelium
Epstein-Barr virus
Health aspects
Herpes simplex
HIV
HIV (Viruses)
Human immunodeficiency virus
Human papillomavirus
Infection
Kinases
Malignancy
Molecular modelling
Mucosa
oropharyngeal mucosal epithelium
Papillomavirus infections
Pathogenesis
reactivation of opportunistic infections
Review
Viruses
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Summary:The oropharyngeal mucosal epithelia have a polarized organization, which is critical for maintaining a highly efficient barrier as well as innate immune functions. In human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) disease, the barrier and innate immune functions of the oral mucosa are impaired via a number of mechanisms. The goal of this review was to discuss the molecular mechanisms of HIV/AIDS-associated changes in the oropharyngeal mucosa and their role in promoting HIV transmission and disease pathogenesis, notably the development of opportunistic infections, including human cytomegalovirus, herpes simplex virus, and Epstein-Barr virus. In addition, the significance of adult and newborn/infant oral mucosa in HIV resistance and transmission was analyzed. HIV/AIDS-associated changes in the oropharyngeal mucosal epithelium and their role in promoting human papillomavirus-positive and negative neoplastic malignancy are also discussed.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11051444