The Role and Application of Exosomes in Gastric and Colorectal Cancer

Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes-small, cell-derived vesicles containing complex RNA and proteins. Exoso...

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Bibliographic Details
Published in:Frontiers in pharmacology 2022-01, Vol.12, p.825475-825475
Main Authors: Li, Qirong, Wang, Dongxu, Ding, Dayong, Feng, Ye, Hou, Ruizhi, Liu, Dianfeng, Lin, Chao, Gao, Yongjian
Format: Article
Language:English
Subjects:
cancer therapy
colorectal cancer
exosomes
gastric cancer
ncRNA
Pharmacology
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Summary:Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes-small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.825475