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p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology

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Bibliographic Details
Published in:	Journal of the American Heart Association 2020-08, Vol.9 (15), p.e017247
Main Authors:	Saleme, Bruno, Das, Subhash K, Zhang, Yongneng, Boukouris, Aristeidis E, Lorenzana Carrillo, Maria Areli, Jovel, Juan, Wagg, Cory S, Lopaschuk, Gary D, Michelakis, Evangelos D, Sutendra, Gopinath
Format:	Article
Language:	English
Subjects:	Animals Antibiotics, Antineoplastic - adverse effects Apelin Receptors - metabolism cardiac metabolism Cardiotoxicity doxorubicin Doxorubicin - adverse effects Energy Metabolism - drug effects Fatty Acids - metabolism Heart - drug effects Humans Male Mice Mice, Nude Myocardium - metabolism p53 Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Research Letter Signal Transduction - drug effects Tumor Suppressor Protein p53 - metabolism
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