New microbial source of the antifungal allylamine “Terbinafine”

The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic anti...

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Bibliographic Details
Published in:Saudi pharmaceutical journal 2017-03, Vol.25 (3), p.440-442
Main Authors: Abdel-Kader, Maged S., Muharram, Magdy M.
Format: Article
Language:English
Subjects:
HRMS
NMR
Short Communication
Streptomyces sp
Structure elucidation
Terbinafine
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Summary:The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic antifungal drug terbinafine marketed under the name “Lamisil”. Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source.
ISSN:1319-0164
2213-7475
DOI:10.1016/j.jsps.2016.06.006