The Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms

Bone marrow fibrosis is the second most common complication that causes morbidity and mortality inpatients with Philadelphia-negative myeloproliferative neoplasms (MPNs). The aim of this study was to investigate theassociation between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patie...

Full description

Saved in:
Bibliographic Details
Published in:Turkish journal of haematology 2012-09, Vol.29 (3), p.242-247
Main Authors: Arı, M Cem, Büyüktaş, Deram, Eşkazan, A Emre, Ongören Aydın, Seniz, Tanrıkulu, Eda, Başlar, Zafer, Buyru, A Nur, Ferhanoğlu, Burhan, Aydın, Yıldız, Tüzüner, Nükhet, Soysal, Teoman
Format: Article
Language:English
Subjects:
bone marrow fibrosis
jak2v617f
myeloproliferative disease
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bone marrow fibrosis is the second most common complication that causes morbidity and mortality inpatients with Philadelphia-negative myeloproliferative neoplasms (MPNs). The aim of this study was to investigate theassociation between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patients with MPNs. In total, 149 patients with MPNs were retrospectively evaluated to determine if there was anassociation between the histological grade of bone marrow fibrosis and JAK2V617F mutation. In all, 67.7% of the patients carried the mutated JAK2 gene. The presence of JAK2V617F mutation was notassociated with the occurrence of bone marrow fibrosis (P=0.55) or its grade at diagnosis (P=0.65). Molecular mechanisms or genetic defects other than JAK2V617F may underlie the occurrence of bonemarrow fibrosis in patients with MPNs.
ISSN:1300-7777
1308-5263
DOI:10.5505/tjh.2012.58751