Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives

18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by spectral data and elemental analyses. The synthesized compounds showed low enzy...

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Bibliographic Details
Published in:Journal of chemistry 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Saglik, Begum Nurpelin, Ozkay, Yusuf, Ozkay, Umide Demir, Gencer, Hulya Karaca
Format: Article
Language:English
Subjects:
Carbamates
Chemical properties
Chemical synthesis
Identification and classification
Methods
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Summary:18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by spectral data and elemental analyses. The synthesized compounds showed low enzyme inhibitory activity. However, they displayed good antimicrobial activity profile. Antibacterial activity of compounds 4a, 4e, and 4p (MIC = 25 μg/mL) was equal to that of chloramphenicol against Klebsiella pneumoniae (ATCC 700603) and Escherichia coli (ATCC 35218). Most of the compounds exhibited notable antifungal activity against Candida albicans (ATCC 10231), Candida glabrata (ATCC 90030), Candida krusei (ATCC 6258), and Candida parapsilosis (ATCC 7330). Moreover, compound 4a, which carries piperidin-1-yl substituent and dimethylthiocarbamoyl side chain as variable group, showed twofold better anticandidal effect against all Candida species than reference drug ketoconazole.
ISSN:2090-9063
2090-9071
DOI:10.1155/2014/387309