Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities

Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, vir...

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Bibliographic Details
Published in:Applied sciences 2020-04, Vol.10 (8), p.2668
Main Authors: Batiha, Gaber El-Saber, Magdy Beshbishy, Amany, Wasef, Lamiaa, Elewa, Yaser H. A., Abd El-Hack, Mohamed E., Taha, Ayman E., Al-Sagheer, Adham Abdullah, Devkota, Hari Prasad, Tufarelli, Vincenzo
Format: Article
Language:English
Subjects:
Abscesses
Acids
Alkaloids
Anti-inflammatory agents
Antioxidants
Apoptosis
Arthritis
Asthma
biological activities
Breast cancer
cat’s claw
Constituents
Drug dosages
Fever
Gene expression
Glycosides
Immune system
Indoles
Infections
Inflammation
Microorganisms
Nonsteroidal anti-inflammatory drugs
Organic acids
Oxidative stress
Parasites
Pharmacokinetics
phytoconstituents
Proanthocyanidins
Rainforests
Sterols
Studies
Triterpenes
Uncaria tomentosa
Urinary tract
Urinary tract diseases
Urinary tract infections
Urogenital system
Viruses
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Summary:Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activities, pharmacokinetics, and toxic properties of U. tomentosa extracts.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10082668