Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial

To investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent of cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy. One hundred twenty patients were randomly divided into D , D , D and NS groups, and dexmedetomidine 0.4, 0.6, 0...

Full description

Saved in:
Bibliographic Details
Published in:BMC anesthesiology 2021-03, Vol.21 (1), p.63-63, Article 63
Main Authors: Ye, Qin, Wang, Fangjun, Xu, Hongchun, Wu, Le, Gao, Xiaopei
Format: Article
Language:English
Subjects:
Adult
Analgesics, Non-Narcotic - pharmacology
Analysis
Anesthesia Recovery Period
Blood pressure
Cardiac arrhythmia
Cardiac patients
Cardiovascular disease
Care and treatment
Cholecystectomy
Cholecystectomy, Laparoscopic - methods
Clinical trials
Cough
Dexmedetomidine
Dexmedetomidine - pharmacology
Dosage
Dose-Response Relationship, Drug
Drug dosages
Extubation
Female
General anesthesia
Haemodynamic stress response
Heart beat
Heart rate
Hemodynamics
Hemodynamics - drug effects
Humans
Hypertension
Intraoperative Period
Intravenous administration
Intubation
Laparoscopic cholecystectomy
Laparoscopic surgery
Laparoscopy
Male
Pain
Pain, Postoperative
Pain, Postoperative - drug therapy
Postoperative pain
Postoperative period
Statistical analysis
Sufentanil
Surgery
Tramadol
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent of cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy. One hundred twenty patients were randomly divided into D , D , D and NS groups, and dexmedetomidine 0.4, 0.6, 0.8μg/kg and normal saline were administrated respectively. Patients' heart rate, systolic blood pressure and diastolic blood pressure were measured at T -T . The incidence of cough was recorded. Other parameters were noted, the time of spontaneous respiratory recovery and extubation, visual analogue scale scores and dosage of tramadol. The heart rate, systolic blood pressure and diastolic blood pressure of D and D groups has smaller fluctuations at T2-3 and T7 compared with NS and D groups (P 
ISSN:1471-2253
1471-2253
DOI:10.1186/s12871-021-01283-z