Analysis of the variable factors affecting changes in the blood concentration of cyclosporine before and after transfusion of red blood cell concentrate

The blood concentration of cyclosporine (CyA) is frequently elevated following the transfusion of red blood cell concentrate (RCC) to patients after allogeneic hematopoietic stem cell transplantation (HSCT). The aim of this retrospective study was to identify the variable factors affecting changes i...

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Bibliographic Details
Published in:Journal of pharmaceutical health care and sciences 2022-02, Vol.8 (1), p.4-4, Article 4
Main Authors: Uchida, Masashi, Hanada, Natsumi, Yamazaki, Shingo, Takatsuka, Hirokazu, Imai, Chiaki, Utsumi, Akari, Shiko, Yuki, Kawasaki, Yohei, Suzuki, Takaaki, Ishii, Itsuko
Format: Article
Language:English
Subjects:
Blood
Cyclosporine
Drug dosages
Hematopoietic stem cell transplantation
Hematopoietic stem cells
Oral administration
Pharmacokinetics
Phosphatases
Plasma
Red blood cell transfusion
Stem cell transplantation
Therapeutic drug monitoring
Transplantation
Transplants & implants
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Summary:The blood concentration of cyclosporine (CyA) is frequently elevated following the transfusion of red blood cell concentrate (RCC) to patients after allogeneic hematopoietic stem cell transplantation (HSCT). The aim of this retrospective study was to identify the variable factors affecting changes in the blood concentration of CyA before and after transfusion of RCC. We enrolled 105 patients (age, 5-66 years) who received both CyA and transfusion after HSCT. The ratio of the measurement after transfusion to the measurement before transfusion was calculated for the hematocrit and blood concentration/dose ratio of CyA (termed the HCT ratio and the CyA ratio, respectively). The blood concentration/dose ratio of CyA was increased after transfusion compared with before transfusion (P 
ISSN:2055-0294
2055-0294
DOI:10.1186/s40780-021-00235-6