Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis

Creatine supplementation is ubiquitously consumed by fitness enthusiasts due to its perceived advantages in enhancing athletic performance. Although there is an increasing concern within this demographic regarding its possible impact on renal function, there is still a lack of rigorous scientific in...

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Bibliographic Details
Published in:Renal failure 2024-12, Vol.46 (2), p.2364762
Main Authors: Zhou, Bing, Hong, Minping, Jin, Liqin, Ling, Keng
Format: Article
Language:English
Subjects:
Acute Kidney Injury
Adult
Creatine - administration & dosage
Creatine supplementation
Dietary Supplements
Female
fitness enthusiasts
Humans
Kidney - physiopathology
Male
Mendelian randomization
Mendelian Randomization Analysis
Middle Aged
renal function
Reproducibility of Results
Surveys and Questionnaires
Young Adult
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Summary:Creatine supplementation is ubiquitously consumed by fitness enthusiasts due to its perceived advantages in enhancing athletic performance. Although there is an increasing concern within this demographic regarding its possible impact on renal function, there is still a lack of rigorous scientific investigations into this alleged association. Data were collected through an online survey on the participants' demographics, creatine usage and concerns related to renal function. The reliability and validity of the survey were assessed using SPSS software. A total of 1129 participants responded to the survey, and chi-square tests were utilized for data analysis. To explore the potential association between creatine levels (as the exposure) and renal function (as the outcome), we utilized open-access genetic databases, and Mendelian randomization (MR) techniques were used to confirm this correlation. Chi-square analysis revealed no significant association between creatine usage and renal function among the participants. Our MR analysis further supported this finding, demonstrating no significant association between creatine levels and six indicators assessing renal function (IVW, all with values exceeding 0.05). Similar values were consistently observed across other MR methods, confirming the absence of a statistical correlation. This MR study offers compelling evidence indicating that creatine levels are not statistically associated with renal function, suggesting the potential to alleviate concerns within the fitness community and emphasizing the significance of evidence-based decision-making when considering nutritional supplementation.
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2024.2364762