Cerebral hemodynamic and metabolic changes in fulminant hepatic failure

ABSTRACT Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mec...

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Published in:Arquivos de neuro-psiquiatria 2017-07, Vol.75 (7), p.470-476
Main Authors: Paschoal, Fernando Mendes, Nogueira, Ricardo de Carvalho, Oliveira, Marcelo de Lima, Paschoal, Eric Homero Albuquerque, Teixeira, Manoel Jacobsen, D’Albuquerque, Luiz Augusto Carneiro, Bor-Seng-Shu, Edson
Format: Article
Language:English
Subjects:
brain edema
Brain Edema - etiology
Brain Edema - physiopathology
Cerebrovascular Circulation - physiology
Hepatic Encephalopathy - etiology
Hepatic Encephalopathy - metabolism
Hepatic Encephalopathy - physiopathology
hepatic insufficiency
Humans
intracranial hypertension
Intracranial Hypertension - etiology
Intracranial Hypertension - physiopathology
Liver Failure, Acute - complications
Liver Failure, Acute - metabolism
Liver Failure, Acute - physiopathology
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PSYCHIATRY
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Summary:ABSTRACT Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.
ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1590/0004-282X20170076