Structural Insights into the Intrinsically Disordered GPCR C-Terminal Region, Major Actor in Arrestin-GPCR Interaction

Arrestin-dependent pathways are a central component of G protein-coupled receptor (GPCRs) signaling. However, the molecular processes regulating arrestin binding are to be further illuminated, in particular with regard to the structural impact of GPCR C-terminal disordered regions. Here, we used an...

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Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-04, Vol.12 (5), p.617
Main Authors: Guillien, Myriam, Mouhand, Assia, Fournet, Aurélie, Gontier, Amandine, Martí Navia, Aleix, Cordeiro, Tiago N, Allemand, Frédéric, Thureau, Aurélien, Banères, Jean-Louis, Bernadó, Pau, Sibille, Nathalie
Format: Article
Language:English
Subjects:
Arrestin
Biochemistry, Molecular Biology
Cloning
G protein-coupled receptors
Ghrelin
GPCR
Growth hormones
intrinsically disordered proteins or regions (IDPs/IDRs)
Kinases
Life Sciences
NMR
Nuclear magnetic resonance
Phosphorylation
Protein structure
Proteins
Secondary structure
Sensors
Signal transduction
Vasopressin
Vasopressin V2 receptors
X-rays
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creator Guillien, Myriam
Mouhand, Assia
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Gontier, Amandine
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Banères, Jean-Louis
Bernadó, Pau
Sibille, Nathalie
description Arrestin-dependent pathways are a central component of G protein-coupled receptor (GPCRs) signaling. However, the molecular processes regulating arrestin binding are to be further illuminated, in particular with regard to the structural impact of GPCR C-terminal disordered regions. Here, we used an integrated biophysical strategy to describe the basal conformations of the C-terminal domains of three class A GPCRs, the vasopressin V2 receptor (V2R), the growth hormone secretagogue or ghrelin receptor type 1a (GHSR) and the β2-adernergic receptor (β2AR). By doing so, we revealed the presence of transient secondary structures in these regions that are potentially involved in the interaction with arrestin. These secondary structure elements differ from those described in the literature in interaction with arrestin. This suggests a mechanism where the secondary structure conformational preferences in the C-terminal regions of GPCRs could be a central feature for optimizing arrestins recognition.
doi_str_mv 10.3390/biom12050617
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subjects Arrestin
Biochemistry, Molecular Biology
Cloning
G protein-coupled receptors
Ghrelin
GPCR
Growth hormones
intrinsically disordered proteins or regions (IDPs/IDRs)
Kinases
Life Sciences
NMR
Nuclear magnetic resonance
Phosphorylation
Protein structure
Proteins
Secondary structure
Sensors
Signal transduction
Vasopressin
Vasopressin V2 receptors
X-rays
title Structural Insights into the Intrinsically Disordered GPCR C-Terminal Region, Major Actor in Arrestin-GPCR Interaction
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