Bio-Inspired Self-Healing, Shear-Thinning, and Adhesive Gallic Acid-Conjugated Chitosan/Carbon Black Composite Hydrogels as Suture Support Materials

The occurrence of leakage from anastomotic sites is a significant issue given its potential undesirable complications. The management of anastomotic leakage after gastrointestinal surgery is particularly crucial because it is directly associated with mortality and morbidity in patients. If adhesive...

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Bibliographic Details
Published in:Biomimetics (Basel, Switzerland) Switzerland), 2023-11, Vol.8 (7), p.542
Main Authors: Shin, Hyun Ho, Ryu, Ji Hyun
Format: Article
Language:English
Subjects:
Acids
Adhesives
Anastomosis
Anastomotic leak
Aqueous solutions
Biocompatibility
Biomedical engineering
Carbon
Carbon black
Chemical properties
Chitin
Chitosan
Colloids
Colorectal surgery
Fecal incontinence
Gallic acid
gallic acid-conjugated chitosan
Graphene
Health aspects
Hydrogels
Hydrogen bonds
Mechanical properties
Morbidity
Nanoparticles
NMR
Nuclear magnetic resonance
Performance evaluation
Phenols
Polymers
Polyvinyl alcohol
Prevention
Production processes
Rheology
self-healing
Shear tests
shear-thinning
Spectrum analysis
Surgical anastomosis
suture support
Sutures
Thinning
tissue adhesives
Toxicity
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Summary:The occurrence of leakage from anastomotic sites is a significant issue given its potential undesirable complications. The management of anastomotic leakage after gastrointestinal surgery is particularly crucial because it is directly associated with mortality and morbidity in patients. If adhesive materials could be used to support suturing in surgical procedures, many complications caused by leakage from the anastomosis sites could be prevented. In this study, we have developed self-healing, shear-thinning, tissue-adhesive, carbon-black-containing, gallic acid-conjugated chitosan (CB/Chi-gallol) hydrogels as sealing materials to be used with suturing. The addition of CB into Chi-gallol solution resulted in the formation of a crosslinked hydrogel with instantaneous solidification. In addition, these CB/Chi-gallol hydrogels showed enhancement of the elastic modulus (G') values with increased CB concentration. Furthermore, these hydrogels exhibited excellent self-healing, shear-thinning, and tissue-adhesive properties. Notably, the hydrogels successfully sealed the incision site with suturing, resulting in a significant increase in the bursting pressure. The proposed self-healing and adhesive hydrogels are potentially useful in versatile biomedical applications, particularly as suture support materials for surgical procedures.
ISSN:2313-7673
2313-7673
DOI:10.3390/biomimetics8070542