Unruptured cerebral aneurysms in elderly patients: key challenges and management

• Published in: Annals of medicine (Helsinki) 2021-01, Vol.53 (1), p.1839-1849
• Main Authors: Caffes, Nicholas, Wenger, Nicole, Cannarsa, Gregory, Oliver, Jeffrey, Onwukwe, Chimdiya, Gandhi, Dheeraj, Simard, J. Marc
• Format: Article
• Language: English
• Subjects: Aged; aneurysms; challenges; Cognitive Dysfunction; Elderly; endovascular; Frailty; Humans; Intracranial Aneurysm - diagnosis; Intracranial Aneurysm - pathology; Intracranial Aneurysm - surgery; Life Expectancy; microsurgery; Neurology; Prognosis; Review; Treatment Outcome; unruptured; Vascular Surgical Procedures - mortality
• ISSN: 0785-3890; 1365-2060
• DOI: 10.1080/07853890.2021.1990393

Unruptured cerebral aneurysms are increasingly identified in elderly patients as the global life expectancy continues to rise and non-invasive vascular imaging becomes more prevalent. The optimal management of unruptured aneurysms in elderly patients remains controversial. Variability in life expectancy, comorbidities and rupture risk coupled with heterogenous endovascular and surgical treatments contribute to a paucity of clear guidelines, and current management is highly individualized. Elderly patients present unique considerations including frailty, cognitive dysfunction, vasculopathy, reduced life expectancy and overall worse prognosis in case of rupture which shape the risks and likelihood of success of endovascular and microsurgical treatment. In this review, we provide a comprehensive overview of unruptured cerebral aneurysms in the elderly, with a particular focus on the natural history, key challenges associated with advanced age, management and future innovations to further refine treatment. Key Messages The management of unruptured cerebral aneurysms in elderly patients remains controversial. Key challenges including frailty, cognitive dysfunction, reduced life expectancy, vasculopathy and poor prognosis with aneurysm rupture add complexity to endovascular and surgical decision making not encountered with younger demographics. A thorough understanding of available treatment options, likelihood of treatment success and associated risks weighed against the risk of aneurysm rupture informs patient discussion and management.