Assessment of in-vivo anti-diabetic and anti-diarrheal effects of Flemingia stricta Roxb. leaf

• Published in: European Journal of Biological Research 2020-05, Vol.10 (2), p.156-166
• Main Authors: Biozid, Md Shahrear, Alam, Mohammad Nazmul, Abeden, Md Jainul, Faruk, Md, Chowdhury, Ahmad Ibtehaz, Sajib, Muzahidul Islam, Rahman, Md Masudur, Islam, Md Rafikul
• Format: Article
• Language: English
• Subjects: Alloxan; Anti-diabetic; Anti-diarrheal; Body weight; Diabetes; Diabetes mellitus; Diarrhea; Flemingia; Flemingia stricta; Gastric motility; Intestinal motility; Intestine; Leaves; Loperamide; Metformin; Methanol; Motility; Oils & fats; Rodents
• ISSN: 2449-8955
• DOI: 10.5281/zenodo.3839749

The objective of this study was to evaluate the anti-diabetic and anti-diarrheal activity of methanol extract of Flemingia stricta Roxb. (Fabaceae) leaf. In anti-diabetic study, the extract was administered to alloxan-induce diabetic mice at two concentrations (200 mg/kg and 400 mg/kg body weight) for acute (12 hours) and prolong treatments (15 days) and blood glucose levels of diabetic mice were monitored at intervals of hours and days throughout the duration of treatment. Antidiarrheal test was conducted by castor oil induced diarrhea and enteropooling as well as intestinal motility in mice at three different concentration (100 mg/kg, 200 mg/kg and 400 mg/kg body weight). Treatment of alloxan induce diabetic mice with the extract caused a significant reduction in fasting blood glucose level of the diabetic mice both in acute (12 hours) and prolong treatment (15 days) and it was determined that the F. stricta methanol extract at both concentration (200 mg/kg and 400 mg/kg) showed the significant (P