Antibacterial and Anti-Inflammatory Polysaccharide from Fructus Ligustri Lucidi Incorporated in PVA/Pectin Hydrogels Accelerate Wound Healing

In cutaneous wound healing, an overproduction of inflammatory chemokines and bacterial infections impedes the process. Hydrogels can maintain a physiologically moist microenvironment, absorb chemokines, prevent bacterial infection, inhibit bacterial reproduction, and facilitate wound healing at a wo...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-03, Vol.29 (7), p.1423
Main Authors: Xi, Yanli, Hu, Lianxin, Chen, Xiang, Zuo, Lili, Bai, Xuesong, Du, Weijie, Xu, Na
Format: Article
Language:English
Subjects:
Analgesics
Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents - pharmacology
antibacterial activity
Chemokines
Collagen Type I
Contact angle
Equilibrium
Fructus Ligustri Lucidi polysaccharides
Hydrogels
Ligustrum
NMR
Nuclear magnetic resonance
pectin
Pectins - pharmacology
Polysaccharides - pharmacology
Polyvinyl Alcohol
Tissue engineering
Toxicity
Ulcers
Wound Healing
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Summary:In cutaneous wound healing, an overproduction of inflammatory chemokines and bacterial infections impedes the process. Hydrogels can maintain a physiologically moist microenvironment, absorb chemokines, prevent bacterial infection, inhibit bacterial reproduction, and facilitate wound healing at a wound site. The development of hydrogels provides a novel treatment strategy for the entire wound repair process. Here, a series of polysaccharide extracts loaded with polyvinyl alcohol (PVA) and pectin hydrogels were successfully fabricated through the freeze-thaw method. A hydrogel containing a 1% mixing weight ratio of FLL-E (named PVA-P-FLL-E1) demonstrated excellent physicochemical properties such as swellability, water retention, degradability, porosity, 00drug release, transparency, and adhesive strength. Notably, this hydrogel exhibited minimal cytotoxicity. Moreover, the crosslinked hydrogel, PVA-P-FLL-E1, displayed multifunctional attributes, including significant antibacterial properties, earlier re-epithelialization, production of few inflammatory cells, the formation of collagen fibers, deposition of collagen I, and faster remodeling of the ECM. Consequently, the PVA-P-FLL-E1 hydrogel stands out as a promising wound dressing due to its superior formulation and enhanced healing effects in wound care.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29071423