Worldwide Distribution and Extracutaneous Manifestations of Henoch-Schönlein Purpura in Adults: Narrative Review

Henoch-Schönlein purpura (HSP), a leukocytoclastic small vessel vasculitis, exhibits both cutaneous and systemic manifestations. While predominantly observed in childhood, it may manifest in adults with more pronounced systemic involvement. Furthermore, HSP is a global phenomenon showcasing epidemio...

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Bibliographic Details
Published in:JMIR dermatology 2024-01, Vol.7, p.e49746-e49746
Main Authors: Harris, Blair W, Maxfield, Luke, Hunter, Abigail, Alhajj, Mandy, Ban, Byung, Pulsipher, Kayd J
Format: Article
Language:English
Subjects:
Abdomen
Adults
Age
Arthritis
Asian studies
Edema
Gender
Geography
Hematuria
Immunoglobulins
Kidneys
Pain
Pediatrics
Purpura
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Summary:Henoch-Schönlein purpura (HSP), a leukocytoclastic small vessel vasculitis, exhibits both cutaneous and systemic manifestations. While predominantly observed in childhood, it may manifest in adults with more pronounced systemic involvement. Furthermore, HSP is a global phenomenon showcasing epidemiological and systemic variances. This study aims to scrutinize extracutaneous manifestations in adults with HSP, discerning distinctions according to geographical regions on a worldwide scale. A comprehensive search encompassing PubMed, Embase, Cochrane Library, and Web of Science was executed, covering papers published from January 1, 1970, to December 1, 2019. Keywords used included "Henoch-Schönlein purpura," "henoch schonlein purpura+adult," "IgA vasculitis+adult," "HSP+adult," and "IgAV." A total of 995 publications were identified, from which 42 studies encompassing 4064 patients were selected, with a predominant focus on cases reported in Asia, Europe, and the Americas. Among adults afflicted with HSP, European patients exhibited a higher propensity for male predominance (P
ISSN:2562-0959
2562-0959
DOI:10.2196/49746