Impact of Desaturation Patterns versus Apnea-Hypopnea Index in the Development of Cardiovascular Comorbidities in Obstructive Sleep Apnea Patients

Various phenotypes of obstructive sleep apnea (OSA) have been recently described and are poorly assessed by the commonly used polysomnographic indices, such as the apnea-hypopnea index and oxygen desaturation index. Nocturnal hypoxemia is the hallmark of OSA and new quantitative markers, as hypoxic...

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Bibliographic Details
Published in:Nature and science of sleep 2022-08, Vol.14, p.1457-1468
Main Authors: Blekic, Nathan, Bold, Ionela, Mettay, Thomas, Bruyneel, Marie
Format: Article
Language:English
Subjects:
Analysis
apnea-hypopnea index
Belgium
Body mass index
Cardiovascular disease
Comorbidity
Electroencephalography
Health aspects
home sleep apnea testing
Hypoxemia
Hypoxia
hypoxic burden
Insomnia
Mortality
Obesity
obstructive sleep apnea
Oxidative stress
oxygen desaturation index
polysomnography
Prognosis
Review
Sleep apnea
Sleep apnea syndromes
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Description
Summary:Various phenotypes of obstructive sleep apnea (OSA) have been recently described and are poorly assessed by the commonly used polysomnographic indices, such as the apnea-hypopnea index and oxygen desaturation index. Nocturnal hypoxemia is the hallmark of OSA and new quantitative markers, as hypoxic burden or desaturation severity, have been shown to be associated with cardiovascular (CV) mortality. The purpose of this overview is to review the endophenotypical and clinical characteristics of OSA, the current metrics, and to analyze different measurements of hypoxemia in OSA to predict the cardiovascular impact (eg hypoxic burden). Potential interest of multidimensional models to classify OSA, such as BAVENO classification, is also discussed, with the goal of focusing on specific endophenotypes that are likely to develop CV comorbidities, in order to guide clinicians to more aggressive management of OSA in these individuals.
ISSN:1179-1608
1179-1608
DOI:10.2147/NSS.S374572