Can locally applied risedronate be an effective agent when combined with xenografts? An animal study

To examine the effects of local risedronate application with xenografts on healing of rabbit skull defects using histological, histomorphometric, immunohistochemical, and three-dimensional radiological methods. Two critical-sized defects with a diameter of 10 mm were created in 16 rabbits and filled...

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Bibliographic Details
Published in:BMC oral health 2023-07, Vol.23 (1), p.514-514, Article 514
Main Authors: Özer, Taha, Guliyeva, Vusala, Aktaş, Alper, Barış, Emre, Ocak, Mert
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Bisphosphonates
Bone Density
Bone grafts
Bone histomorphometry
Bone Regeneration
Bone Transplantation
Bones
Collagen
Density
Dosage and administration
Heterografts
Humans
Humidity
Immunohistochemistry
Ketamine
Laboratory animals
Osteoconduction
Osteopontin
Particle size
Patient outcomes
Rabbits
Risedronate
Risedronic Acid
Skin & tissue grafts
X-ray microtomography
Xenografts
Xenotransplantation
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Summary:To examine the effects of local risedronate application with xenografts on healing of rabbit skull defects using histological, histomorphometric, immunohistochemical, and three-dimensional radiological methods. Two critical-sized defects with a diameter of 10 mm were created in 16 rabbits and filled with xenogenic bone graft and xenogenic bone graft + 5 mg risedronate in the control I and risedronate (RIS) groups, respectively. Residual graft, new bone, soft tissue areas, and bone volume were evaluated in the 4- and 8-week study groups. In both the 4- and 8-week samples, the RIS group samples had significantly higher mean new bone area values than the C group (p 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-023-03231-4