Pretreatment with egg white hydrolysate protects resistance arteries from damage induced after treatment with accidental cadmium exposure values

• Published in: Journal of functional foods 2023-05, Vol.104, p.105529, Article 105529
• Main Authors: Piagette, Janaína Trindade, Pinheiro Júnior, José Eudes Gomes, Kanaan, Samia Hassan Husein, Herrera, Camila Teixeira, Bastilhos, Leandro Ortiz, Peçanha, Franck Maciel, Vassallo, Dalton Valentim, Miguel-Castro, Marta, Wiggers, Giulia Alessandra
• Format: Article
• Language: English
• Subjects: Apoptosis; Cadmium; Egg white hydrolysate; Inflammation; Oxidative stress; Vascular dysfunction
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2023.105529

[Display omitted] •EWH pretreatment prevents the SBP increase and vascular dysfunction caused by Cd.•EWH pretreatment prevented the increase of oxidative stress caused by Cd in MRA.•EWH pretreatment prevents the increase of pro-inflammatory markers induced by Cd.•EWH pretreatment protects MRA from Caspase-3 activation, an apoptotic protease. We investigated whether pretreatment with an egg white hydrolysate (EWH) protects the cardiovascular system, especially the resistance vessels, from damage promoted by Cd exposure at high levels. Male Wistar rats, divided into groups: 1) Control – tap water by gavage + distilled water i.p. (28 days); 2) Cd – tap water (28 days) + CdCl2 1 mg/kg i.p. (last 14 days); 3) EWH 1 mg/kg/day by gavage + distilled water i.p. (28 days); 4) EWHCd – EWH (first 14 days) and CdCl2 i.p. + EWH (last 14 days). EWH pretreatment protected against vascular damage occurring in mesenteric resistance arteries (MRA) after exposure to elevated Cd levels by reducing the increased vascular contractile response. Pretreatment with EWH maintained SBP at control levels, protected against increased oxidative stress through NOX1 pathway, prevented triggering of inflammatory cascades (COX-2, TNFα, NF-κB), and protected MRA from Caspase-3 activation induced by Cd, an important apoptotic protease.