Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease

Diabetic heart disease (DHD) is a serious complication in patients with diabetes. Despite numerous studies on the pathogenic mechanisms and therapeutic targets of DHD, effective means of prevention and treatment are still lacking. The pathogenic mechanisms of DHD include cardiac inflammation, insuli...

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Bibliographic Details
Published in:Cardiovascular diabetology 2024-05, Vol.23 (1), p.169-17, Article 169
Main Authors: Zhang, Chaoyue, Shi, Yunke, Liu, Changzhi, Sudesh, Shivon Mirza, Hu, Zhao, Li, Pengyang, Liu, Qi, Ma, Yiming, Shi, Ao, Cai, Hongyan
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - therapeutic use
Antidiabetics
Body fat
Cardiomyocytes
Cardiovascular disease
Chemokines
Cytokines
Diabetes
Diabetes mellitus
Diabetic Cardiomyopathies - drug therapy
Diabetic Cardiomyopathies - etiology
Diabetic Cardiomyopathies - immunology
Diabetic Cardiomyopathies - metabolism
Diabetic cardiomyopathy
Diabetic heart disease
Drug delivery
Drug development
Drug therapy
Fibrosis
Glucose
Health risks
Heart
Heart diseases
Homeostasis
Humans
Hyperglycemia
Immune system
Immunosuppressive agents
Inflammation
Inflammation Mediators - metabolism
Innate immunity
Insulin Resistance
Kinases
Lipids
Macrophages
Macrophages - drug effects
Macrophages - immunology
Macrophages - metabolism
Metabolism
Molecular Targeted Therapy
Myocardium - immunology
Myocardium - metabolism
Myocardium - pathology
Neutrophils
Oxidative stress
Oxidative Stress - drug effects
Proteins
Review
Signal Transduction
Therapeutic targets
Tumor necrosis factor-TNF
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Summary:Diabetic heart disease (DHD) is a serious complication in patients with diabetes. Despite numerous studies on the pathogenic mechanisms and therapeutic targets of DHD, effective means of prevention and treatment are still lacking. The pathogenic mechanisms of DHD include cardiac inflammation, insulin resistance, myocardial fibrosis, and oxidative stress. Macrophages, the primary cells of the human innate immune system, contribute significantly to these pathological processes, playing an important role in human disease and health. Therefore, drugs targeting macrophages hold great promise for the treatment of DHD. In this review, we examine how macrophages contribute to the development of DHD and which drugs could potentially be used to target macrophages in the treatment of DHD.
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-024-02273-4